A common trend in the design of large-scale clusters is to use a high-performanc e data network to integrate the processing nodes in a single parallel computer. In these systems the performance of the interconnect can be a limiting factor for the input/output (I/O), which is traditionally bottlenecked by the disk bandwidth. In this paper we present an experimental analysis on a 64-node AlphaServer cluster based on the Quadrics network (QsNET) of the behavior of the interconne ct under I/O traffic, and the influence of the placement of the I/O servers on the overall performance. The effects of using dedicated I/O nodes or overlapping I/O and computation on the I/O nodes are also analyzed. In addition, we evaluate how background I/O traffic interferes with other parallel applications running concurrently. Our experimental results show that a correct placement of the I/O servers can provide up to 20% increase in the available I/O bandwidth. Moreover, some important guidelines for applications and I/O servers mapping on large-scale clusters are given.